1-benzyl-2,3-dihydroindole-5-carbaldehyde → 5-Methylindoline

HRID 1108477노트

반응식

HRID 1108477 반응식
C([N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH:17]=O)=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[CH3:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[NH:8][CH2:9][CH2:10]2

참가 물질

5

반응물 2

HCID 9275671-benzyl-2,3-dihydroindole-5-carbaldehydeHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 140236795-Methylindoline수율 80.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Into a 200 mλ atmospheric pressure hydrogenation apparatus equipped with a thermometer and a stirrer, 2.0 g (0.0084 mol) of 1-benzyl-5-formylindoline, 0.4 g of 5% 5 Pd/C and 100 mλ of ethanol were charged, and while introducing hydrogen under atmospheric pressure, a reaction was carried out at from 60 to 70° C. for 8 hours, and when the absorption of hydrogen ceased, the reaction was terminated. After termination of the reaction, the lo palladium catalyst (5% Pd/C) was collected by filtration, and ethanol was distilled off under reduced pressure to obtain a slightly red liquid. The obtained liquid was subjected to vacuum distillation to obtain 0.9 g of 5-methylindoline having a boiling point of 93° C./4 mmHg. The yield was 80.4% (based on the 1-benzyl-5-formylindoline).

후처리

  1. additionwere charged
  2. customwhen the absorption of hydrogen
  3. customthe reaction was terminated
  4. customAfter termination of the reaction
  5. filtrationthe lo palladium catalyst (5% Pd/C) was collected by filtration, and ethanol
  6. distillationwas distilled off under reduced pressure
  7. customto obtain a slightly red liquid
  8. distillationThe obtained liquid was subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-fe2d1e3a362d4652b66c40faa6b31731
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06066744

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