Hydroquinone → 1-(2-Methacryloyloxyethyl)indole

HRID 1108540노트

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HRID 1108540 반응식
Cl[CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1.[C:13]([O-:18])(=[O:17])[C:14]([CH3:16])=[CH2:15].[K+].[I-].[K+].C1(C=CC(O)=CC=1)O>CN(C)C=O>[C:13]([O:18][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1)(=[O:17])[C:14]([CH3:16])=[CH2:15]

참가 물질

6

반응물 4

HCID 785HydroquinoneHCID 4875Potassium IodideHCID 108992601-(2-chloroethyl)-1H-indoleHCID 23667354Potassium methacrylate

생성물 1

HCID 184697791-(2-Methacryloyloxyethyl)indole수율 78.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Subsequently, 1-(2-chloroethyl)indole (15.4 g), potassium methacrylate (21.3 g), potassium iodide (7.1 g), N,N-dimethylformamide (40 ml), and a small amount of hydroquinone were placed in a 200-ml flask equipped with a stirrer and a condenser tube. The mixture was heated to 100° C. and stirred for 2.5 hours. After completion of reaction, insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure. This reaction mixture was purified further by silica gel column chromatography to obtain 1-(2-methacryloyloxyethyl) indole (15.5 g).

후처리

  1. customequipped with a stirrer and a condenser tube
  2. customAfter completion of reaction, insoluble matter
  3. customwas removed by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customThis reaction mixture was purified further by silica gel column chromatography

출처 및 근거

ORD 기록
ord-cbd6d095bfb2494e95f2835fc96b22b3
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06068963

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