Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromide ion → (2-Chloro-5-methoxybenzyl)(triphenyl)phosphonium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromide ion | HCID 259 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 1-Chloro-4-methoxy-2-methylbenzene | HCID 458156 | — |
| 반응물 | Nbs aibn | HCID 86630000 | — |
| 용매 | Methane, dichloro-, compd. with benzene (1:1) | HCID 23443464 | — |
| 생성물 | (2-Chloro-5-methoxybenzyl)(triphenyl)phosphonium bromide | HCID 85758264 | 76% |
반응 단계
Bromination of 1-chloro-4-methoxy-2-methylbenzene with NBS/AIBN, followed by reaction of the crude bromide with triphenylphosphine, using the procedure described in example 102, except that the reaction time for the bromination was 4 h, gave the phosphonium salt (578) (76%) as a light brown solid, mp (CH2Cl2/benzene) 189–190.5° C. 1H NMR (CDCl3) δ 7.82–7.61 (m, 15H), 7.21 (t, J=2.8 Hz, 1H), 7.04 (dd, J=8.8, 0.8 Hz, 1H), 6.76 (dt, J=8.9, 2.7 Hz, 1H), 5.59 (d, J=14.4 Hz, 2H), 3.58 (s, 3H). Found: C, 62.75; H, 4.70. C26H23BrClOP requires-C, 62.73; H, 4.66.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094798B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-bfdc92081d604501937dbab0c74fb0e9 |
| 출처 메모 | uspto-grants-2006_08 |