Potassium Carbonate → Methyl 2-acetamido-3-hydroxybenzoate

HRID 1108697노트

반응식

HRID 1108697 반응식
[C:1]([NH:4][C:5]1[C:14]([O:15]C(=O)C)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([NH:4][C:5]1[C:14]([OH:15])=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 22627220Methyl 2-acetamido-3-acetoxybenzoate

생성물 1

HCID 22627296Methyl 2-acetamido-3-hydroxybenzoate수율 84.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 2-acetamido-3-acetoxybenzoate (1.72 g) in methanol (9 ml) was added powdered potassium carbonate (1.4 g), and the mixture was stirred for 20 minutes. The resulting solid was removed by filtration and washed with methanol. The filtrate was evaporated in vacuo, and the residue was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was triturated with a mixture of isopropyl ether and hexane to give methyl 2-acetamido-3-hydroxybenzoate (1.21 g) as solid.

후처리

  1. customThe resulting solid was removed by filtration
  2. washwashed with methanol
  3. customThe filtrate was evaporated in vacuo
  4. extractionextracted with ethyl acetate
  5. washThe organic phase was washed with brine
  6. dry with materialdried over sodium sulfate
  7. customevaporated in vacuo
  8. customThe residue was triturated with a mixture of isopropyl ether and hexane

출처 및 근거

ORD 기록
ord-225e37ea3c444009a4a3efc08272aa06
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06069156

반응 노트

불러오는 중…