Toluene → 2,2-Difluoro-4-pentenoyl chloride

HRID 1108840

반응식

HRID 1108840 반응식
[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3](O)=[O:4].[Cl:10]CCl.C1(C)C=CC=CC=1>CN(C)C=O>[F:1][C:2]([F:9])([CH2:6][CH:7]=[CH2:8])[C:3]([Cl:10])=[O:4]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 6344DichloromethaneHCID 119546562,2-Difluoro-4-pentenoic acid

생성물 1

HCID 136650492,2-Difluoro-4-pentenoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

For example, 2,2-difluoro-4-pentenoic acid 12c is contacted with about 1.0 to 1.5 molar equivalents of an appropriate chlorinating agent. The reaction is carried out in a suitable solvent, such as dichloromethane, toluene or dimethylformamide. The reaction is carried out at a temperature of from about 20° C. to about 35° C. and generally requires about 4 to 24 hours. The product, 2,2-difluoro-4-pentenoyl chloride 12a, can be isolated by fractional distillation and purified by techniques well known in the art, such as chromatography.

후처리

  1. customis carried out at a temperature of from about 20° C. to about 35° C. and generally requires about 4 to 24 hours

출처 및 근거

ORD 기록
ord-be5464b05475445dacc2fdd84dfe48c2
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06069232

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