Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(2-Mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine → HCID 178482393, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(2-Mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine | HCID 181798 | — |
| 반응물 | N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine | HCID 1967272 | — |
| 반응물 | Nizax | HCID 3033637 | — |
| 생성물 | HCID 178482393 | HCID 178482393 | — |
반응 단계
The preparation of nizatidine by fusing 4-chloromethyl-2-dimethylaminomethylthiazole with N-(2-mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine has been suggested generically in EP 49618. However, we have found that N-(2-mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine cannot be isolated and stored. Our attempts to prepare this compound have always produced the disulphide, N-methyl-[N'-[2-(N"-methyl-2-nitro-1,1-ethenediamine)ethyldisulphanyl]ethyl]-2-nitro-1,1-ethenediamine and 3-methylamino-5,6-dihydro-[1,4]-thiazin-2-one oxime.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06069256 |
| 출처 데이터셋 | uspto-grants-2000_05 |
| ORD ID | ord-d4c2628f636343c0950d985ab13926c3 |
| 출처 메모 | uspto-grants-2000_05 |