Hypochlorous Acid → N-chloro-2-methyl valeramide

참여 물질

반응 단계

A stirred suspension of 2-ethyl valeramide (33.0 g, 286 mmol) in 220 ml of ethyl acetate was cooled to 0° and hypochlorous acid (55.25 g of 27.67% solution, 291 mmol) was added over 15 minutes. The cooling bath was removed and stirring continued for 1/2 hour. The organic phase was collected and dried (MgSO4) and the solvent was removed on a rotary evaporator to yield 32.8 g of N-chloro-2-methyl valeramide as a clear yellow liquid.

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