Hypochlorous Acid → N-chlor-2,2-dimethyl valeramide

HRID 1109271

반응식

HRID 1109271 반응식
[CH3:1][C:2]([CH3:9])([CH2:6][CH2:7][CH3:8])[C:3]([NH2:5])=[O:4].[Cl:10]O>C(OCC)(=O)C>[Cl:10][NH:5][C:3](=[O:4])[C:2]([CH3:9])([CH3:1])[CH2:6][CH2:7][CH3:8]

참가 물질

4

반응물 2

HCID 24341Hypochlorous AcidHCID 831802,2-Dimethylpentanamide

생성물 1

HCID 19022270N-chlor-2,2-dimethyl valeramide수율 88.7%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
0 °C

실험 절차

A stirred suspension of 2,2-dimethyl valeramide (35 g, 271 mmol) in ethyl acetate (200 ml) was cooled to 0° C. and hypochlorous acid (40.0 g of 36.2% solution, 276 mmol) was added dropwise over 12 minutes. The resulting clear yellow solution was then stirred for 30 minutes at room temperature, the organic phase separated and dried (MgSO4) and the ethyl acetate removed in vacuo to give 39.35 g of low-melting solid product.

후처리

  1. customthe organic phase separated
  2. dry with materialdried (MgSO4)
  3. customthe ethyl acetate removed in vacuo

출처 및 근거

ORD 기록
ord-47a3c4770d9846749b355cca7ab1d623
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05319133

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