Acetaminophen → Acetamide, N-[4-(2-quinolinylmethoxy)phenyl]-

HRID 1109502

반응식

HRID 1109502 반응식
Cl.Cl[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1.[C:14]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)(=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:14]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:3][C:4]2[CH:13]=[CH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[CH:20][CH:19]=1)(=[O:16])[CH3:15]

참가 물질

5

반응물 3

HCID 1983AcetaminophenHCID 11430Potassium CarbonateHCID 30838232-(Chloromethyl)quinoline hydrochloride

생성물 1

HCID 2747568Acetamide, N-[4-(2-quinolinylmethoxy)phenyl]-

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture containing 2-(chloromethyl)quinoline hydrochloride (100.0 g), 4-acetamidophenol (70.69 g) and milled anhydrous potassium carbonate (194 g) was stirred in DMF (1.2 L) using a mechanical stirrer for 48 hours. The mixture was carefully poured onto ice/water (3 L) with vigourous stirring. After the ice had melted, the solid was filtered and rinsed thoroughly with water. It was recrystallized from 95% ethanol and filtered to give the title compound in three crops.

후처리

  1. customfor 48 hours
  2. additionThe mixture was carefully poured onto ice/water (3 L) with vigourous stirring
  3. filtrationthe solid was filtered
  4. washrinsed thoroughly with water
  5. customIt was recrystallized from 95% ethanol
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-f437e33c3042480d8096c79a88cdfb01
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05321033

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