1,5-Diamino-1,5-dibenzyloxymethyl-3-azapentane → 2,10-Dioxo-4,8-bis(benzyloxymethyl)-13-hydroxy-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane

HRID 1109700노트

반응식

HRID 1109700 반응식
[CH2:1]([O:8][CH2:9][CH:10]([CH2:12][NH:13][CH2:14][CH:15]([CH2:17][O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[NH2:16])[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:28][C:29]([CH:31]1[CH2:36][CH:35]([OH:37])[CH2:34][CH:33]([C:38](OCC)=[O:39])[NH:32]1)=O)C>>[O:39]=[C:38]1[NH:16][CH:15]([CH2:17][O:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:14][NH:13][CH2:12][CH:10]([CH2:9][O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[NH:11][C:29](=[O:28])[CH:31]2[NH:32][CH:33]1[CH2:34][CH:35]([OH:37])[CH2:36]2

참가 물질

3

반응물 2

HCID 194385191,5-Diamino-1,5-dibenzyloxymethyl-3-azapentaneHCID 233626602,6-Bis(ethyloxycarbonyl)-4-hydroxy-piperidine

생성물 1

HCID 190192832,10-Dioxo-4,8-bis(benzyloxymethyl)-13-hydroxy-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane

실험 절차

2,6-Bis(benzyloxymethyl)-1,4,7-triazaheptane (10 mmol), (described in WO-A-89/00557, Example 6 d) and 2,6-bis(ethyloxycarbonyl)-4-hydroxy-piperidine (10 mmol) (described in WO-A-90/08138)is reacted as described in Example 1 a) to yield the title compound.

후처리

  1. customin WO-A-90/08138)is reacted

출처 및 근거

ORD 기록
ord-e17d1ddffa974981907ca762325ce41e
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05322681

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