Sodium Carbonate → 4,5-Dichloro-4-fluoro-3,4,5,6-tetrahydrophthalic anhydride

HRID 1109827

반응식

HRID 1109827 반응식
[Cl:1][C:2]1[CH2:3][C:4]2[C:9](=[O:10])[O:8][C:6](=[O:7])[C:5]=2[CH2:11][CH:12]=1.[Cl:13]N1C(=O)CCC1=O.C1C=CN=CC=1.[FH:27].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[Cl:1][C:2]1([F:27])[CH:12]([Cl:13])[CH2:11][C:5]2[C:6]([O:8][C:9](=[O:10])[C:4]=2[CH2:3]1)=[O:7]

참가 물질

6

반응물 4

HCID 10340Sodium CarbonateHCID 31398ChlorosuccinimideHCID 64774Pyridine, hydrofluoride (1:1)HCID 109869774-Chloro-3,6-dihydrophthalic anhydride

생성물 1

HCID 542227594,5-Dichloro-4-fluoro-3,4,5,6-tetrahydrophthalic anhydride

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

4-chloro-3,6-dihydrophthalic anhydride (0.63 g) and N-chlorosuccinimide (0.47 g) in methylene chloride (6.2 ml) was added to pyridinium poly(hydrogen fluoride) at room temperature. The reaction mixture was stirred for 2 hours and then carefully poured into a two phase system containing solid sodium carbonate and methylene chloride. The suspension was filtered, the methylene chloride layer was dried over magnesium sulfate and the solvent removed under reduced pressure.

후처리

  1. additioncarefully poured into a two phase system
  2. filtrationThe suspension was filtered
  3. dry with materialthe methylene chloride layer was dried over magnesium sulfate
  4. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-4dd89edc0a244d408f3a9325994de888
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05322954

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