3-(1-Azidotridecyl)-5-trimethylsilylfuran → 3-(1-Aminotridecyl)-5-trimethylsilylfuran

HRID 1109875노트

반응식

HRID 1109875 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[N:7]([CH:10]([C:23]1[CH:27]=[C:26]([Si:28]([CH3:31])([CH3:30])[CH3:29])[O:25][CH:24]=1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N+]=[N-]>O1CCCC1>[NH2:7][CH:10]([C:23]1[CH:27]=[C:26]([Si:28]([CH3:31])([CH3:30])[CH3:29])[O:25][CH:24]=1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

참가 물질

4

반응물 2

HCID 190198473-(1-Azidotridecyl)-5-trimethylsilylfuranHCID 21226445Aluminium lithium hydride

생성물 1

HCID 150370773-(1-Aminotridecyl)-5-trimethylsilylfuran

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Lithium aluminum hydride (a 1M solution in tetrahydrofuran; 1.1 ml, 1.1 mmol) was added dropwise to a solution of 3-(1-azidotridecyl)-5-trimethylsilylfuran (334 mg, 0.92 mmol) in tetrahydrofuran at room temperature. After one hour at room temperature, the excess hydride was destroyed by adding acetone slowly to the mixture with cooling. Sodium sulfate (ca. 0.5 g) was added and the mixture was extracted thoroughly with ethyl acetate. Evaporation of the dried (magnesium sulfate) extracts gave an oil, which was purified by flash chromatography on silica using 5% methanol/dichloromethane containing 0.2% triethylamine. Fractions with Rf of about 0.18 on evaporation gave the title amine as a pale yellow oil.

후처리

  1. customthe excess hydride was destroyed
  2. additionby adding acetone slowly to the mixture
  3. temperaturewith cooling
  4. additionSodium sulfate (ca. 0.5 g) was added
  5. extractionthe mixture was extracted thoroughly with ethyl acetate
  6. customEvaporation of the
  7. dry with materialdried (magnesium sulfate)
  8. customextracts gave an oil, which
  9. customwas purified by flash chromatography on silica using 5% methanol/dichloromethane containing 0.2% triethylamine
  10. customFractions with Rf of about 0.18 on evaporation

출처 및 근거

ORD 기록
ord-10663e71131b4233aaafdae9d6d8472e
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05322953

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