Ethanolamine → HCID 19694659, 화합물

HRID 1110노트

반응식

HRID 1110 반응식
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH2:5]([O:19][CH2:20][CH:21]1[O:25][C:22]1([CH3:24])[CH3:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH:21]([CH2:20][O:19][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:22]([CH3:24])([OH:25])[CH3:23]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 196945961-Tetradecyloxy-3-methyl-2-butene oxide

생성물 1

HCID 19694659HCID 19694659, 화합물수율 58%

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
80 °C

실험 절차

A 100-ml two-necked flask equipped with a stirrer and a dropping funnel was charged with 15.3 g (16.7 mmol) of ethanolamine and 5.0 g of ethanol. While heating and stirring the mixture at 80° C. in a nitrogen atmosphere, an ethanol solution of 5.00 g (16.7 mmol) of 1-tetradecyloxy-3-methyl-2-butene oxide was added dropwise over 3 hours. After heating and stirring the mixture further for 16 hours, the resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 3.47 g (yield: 58%) of the title compound (IIc-4).

후처리

  1. customA 100-ml two-necked flask equipped with a stirrer and a dropping funnel
  2. temperatureWhile heating
  3. temperatureAfter heating
  4. stirringstirring the mixture further for 16 hours
  5. customthe resultant reaction mixture
  6. concentrationwas concentrated under reduced pressure
  7. customthe resultant residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-e403979772a141b9b46f8ea7de5203df
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723497

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