Ethanol → ethyl quinoline-2-carboxylate

HRID 1110026노트

반응식

HRID 1110026 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([O:13][CH2:19][CH3:20])=[O:12]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 7124Quinaldic Acid

생성물 1

HCID 421739ethyl quinoline-2-carboxylate

실험 절차

29.89 g of quinoline-2-carboxylic acid were heated under reflux for 51/2 hours in 450 ml of ethanol with the addition of 3.5 ml of sulfuric acid. The reaction mixture was worked up by evaporating it, taking up the residue in water and extracting the mixture with dichloromethane. The organic phase was washed with aqueous sodium bicarbonate solution and then with water until neutral, dried and evaporated. 32.23 g of crude ethyl quinoline-2-carboxylate were obtained as a green oil.

후처리

  1. customby evaporating it
  2. extractionextracting the mixture with dichloromethane
  3. washThe organic phase was washed with aqueous sodium bicarbonate solution
  4. dry with materialwith water until neutral, dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-976e133b766b461e9cb7d0504ebe0de8
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05324725

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