Sodium Carbonate → Spiro[indene-1,4'-piperidine]

HRID 1110044노트

반응식

HRID 1110044 반응식
Cl.[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[Na+].[Na+]>O>[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 22509344Spiro[indene-1,4'-piperidine] hydrochloride

생성물 1

HCID 10330052Spiro[indene-1,4'-piperidine]

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Spiro[1H-indene-1,4'-piperidine]hydrochloride (400 mg, 1.8 mmol), prepared according to Example 1, step 3, was dissolved in water (10 ml), and the solution made alkaline with sodium carbonate. The mixture was extracted with dichloromethane (3×10 ml), the organic layers separated, dried (MgSO4) and evaporated in vacuo. The free base was used without any further purification.

후처리

  1. extractionThe mixture was extracted with dichloromethane (3×10 ml)
  2. customthe organic layers separated
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo
  5. customThe free base was used without any further purification

출처 및 근거

ORD 기록
ord-200b2f52d402459d8bef0f27cc92a81d
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05324733

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