3-Nitro-5-(octadecyloxy)benzoic acid methyl ester → 3-Amino-5-(octadecyloxy)benzoic acid methyl ester

HRID 1110258노트

반응식

HRID 1110258 반응식
[CH3:1][O:2][C:3](=[O:32])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:7]=[C:6]([N+:29]([O-])=O)[CH:5]=1>[Pd].C1COCC1>[CH3:1][O:2][C:3](=[O:32])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH:7]=[C:6]([NH2:29])[CH:5]=1

참가 물질

4

반응물 1

HCID 536989543-Nitro-5-(octadecyloxy)benzoic acid methyl ester

생성물 1

HCID 193890883-Amino-5-(octadecyloxy)benzoic acid methyl ester수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 3.55 g of 3-nitro-5-(octadecyloxy)benzoic acid methyl ester and 0.75 g of 10% palladium on carbon in 100 ml of THF was shaken under an initial hydrogen pressure of 52 psi until uptake ceased after 1.5 hours. The catalyst was removed by filtration and the filtrate was concentrated at reduced pressure to give 3.28 g of pure 3-amino-5-(octadecyloxy)benzoic acid methyl ester.

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated at reduced pressure

출처 및 근거

ORD 기록
ord-442c2d56145e401fb9be993122ddb862
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05324747

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