Ammonia → 2-Cyanoethyl 3-amino-2-butenoate
반응식
[C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[NH3:12]>CO>[NH2:12][C:3]([CH3:5])=[CH:2][C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])=[O:6]참가 물질
4
실험 절차
To 10 mL of methanol was added 20 g (0.13 mole) of 2-cyanoethyl acetoacetate. The solution was cooled in ice and a slow stream of ammonia gas was passed through it for five hours. The reaction flask was stoppered and stored at 0° C. overnight. The resulting solid was collected, washed with a small amount of methanol and dried under high vacuum to give 11.1 g (0.072 mole) of 2-cyanoethyl 3-aminobut-2-enoate, 1H NMR 4.6 (s, 1H), 4.3 (t, 2H), 2.8 (t, 2H), 2.0(t, 3H).
후처리
- temperatureThe solution was cooled in ice
- customThe resulting solid was collected
- washwashed with a small amount of methanol
- customdried under high vacuum
출처 및 근거
- ORD 기록
- ord-659da49c72a340e59d6911e1e26c0d8c
- 출처 데이터셋
- uspto-grants-1990_12
- 특허 번호
- US04975437
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