Ethyl 4-(hydroxymethyl)benzoate → Ethyl 4-formylbenzoate

HRID 1110415

반응식

HRID 1110415 반응식
[OH:1][CH2:2][C:3]1[CH:13]=[CH:12][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][CH:4]=1>[O-2].[O-2].[Mn+4].CCCCCC.C(Cl)(Cl)(Cl)Cl>[CH:2]([C:3]1[CH:13]=[CH:12][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][CH:4]=1)=[O:1]

참가 물질

4

반응물 1

HCID 12480307Ethyl 4-(hydroxymethyl)benzoate

생성물 1

HCID 80498Ethyl 4-formylbenzoate

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 21584008HCID 21584008, 화합물용매

실험 절차

24.1 g (0.277 mmol) of manganese dioxide are added with stirring and at room temperature to a solution of 2.5 g (13.9 mmol) of ethyl 4-(hydroxymethyl)benzoate in an n-hexane/carbon tetrachloride (50 ml : 30 ml) mixture. After half an hour of stirring, the reaction is complete. After filtration of the reaction medium and removal of the solvents under vacuum, 1.76 g of a yellow oil which gives a single spot in TLC are obtained. A crystallization in isopropyl ether yields a white solid.

후처리

  1. filtrationAfter filtration of the reaction medium and removal of the solvents under vacuum, 1.76 g of a yellow oil which
  2. customgives a single spot in TLC
  3. customare obtained
  4. customA crystallization in isopropyl ether
  5. customyields a white solid

출처 및 근거

ORD 기록
ord-32048ce8316e457bb1c9fc001742ff4b
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04975455

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