p-Bromochlorobenzene → 1-Chloro-4-(4-methoxyphenoxy)benzene

HRID 1110657노트

반응식

HRID 1110657 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=1.[OH-].[K+]>[Cu]>[CH3:9][O:10][C:11]1[CH:17]=[CH:16][C:14]([O:15][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][CH:3]=2)=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 7806p-BromochlorobenzeneHCID 90154-MethoxyphenolHCID 14797Potassium Hydroxide

생성물 1

HCID 101054561-Chloro-4-(4-methoxyphenoxy)benzene수율 53.7%

시약·촉매·용매 1

HCID 23978Copper촉매

실험 절차

4-Bromochlorobenzene (3.8 g), hydroquinone monomethyl ether (3.1 g) and potassium hydroxide (1.5 g) and copper powder (0.1 g) were mixed and the reaction was carried out at 160° C. to 200° C. for 3 hours. After cooling to room temperature, the reaction mixture was extracted with benzene (100 ml) and washed with 1N sodium hydroxide, water, and saturated aqueous sodium chloride. After drying over anhydrous magnesium sulfate, the solvent was evaporated under a reduced pressure and the residue was purified by medium pressure column chromatography using silica gel, to obtain 4-(4-chlorophenoxy)phenol methyl ether (2.5 g).

후처리

  1. extractionthe reaction mixture was extracted with benzene (100 ml)
  2. washwashed with 1N sodium hydroxide, water, and saturated aqueous sodium chloride
  3. dry with materialAfter drying over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under a reduced pressure
  5. customthe residue was purified by medium pressure column chromatography

출처 및 근거

ORD 기록
ord-6c734cefce64484499d178a44cd021c7
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04976773

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