Diethylamine → N,N-Diethyl-3-nitrobenzenesulfonamide

HRID 1110672노트

반응식

HRID 1110672 반응식
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[N+:6]([C:9]1[CH:10]=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1)([O-:8])=[O:7]>N1C=CC=CC=1.C(Cl)Cl>[CH2:1]([N:3]([CH2:4][CH3:5])[S:15]([C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([N+:6]([O-:8])=[O:7])[CH:10]=1)(=[O:16])=[O:17])[CH3:2]

참가 물질

5

반응물 2

HCID 8021DiethylamineHCID 84763-Nitrobenzenesulfonyl chloride

생성물 1

HCID 232031N,N-Diethyl-3-nitrobenzenesulfonamide수율 51.2%

시약·촉매·용매 2

HCID 1049Pyridine용매2회HCID 6344Dichloromethane용매

반응 조건

온도
50 °C

실험 절차

Diethylamine (2.4 g) was dissolved in pyridine (15 ml) and 3-nitrobenzenesulfonyl chloride (6.7 g) was added, followed by stirring at 50° C. for 2 hours. The residue obtained by an evaporation of pyridine under a reduced pressure was dissolved in methylene chloride (150 ml), washed with water, 1N hydrochloric acid, water, and saturated aqueous sodium chloride, and dried over anhydrous sodium sulfate. Evaporation of the solvent under a reduced pressure gave N,N-diethyl-3-(nitro)benzenesulfonamide (4.0 g).

후처리

  1. washwashed with water, 1N hydrochloric acid, water, and saturated aqueous sodium chloride
  2. dry with materialdried over anhydrous sodium sulfate
  3. customEvaporation of the solvent under a reduced pressure

출처 및 근거

ORD 기록
ord-aa3aa13b3bb74602b666f316a8a8d088
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04976773

반응 노트

불러오는 중…