Tris(hydroxymethyl)aminomethane → Prinomide Tromethamine

HRID 1110851

반응식

HRID 1110851 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:20])[CH:8]([C:11](=[O:19])[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:9]#[N:10].[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24]>C(O)C>[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24].[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:20])[CH:8]([C:11](=[O:19])[NH:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:9]#[N:10]

참가 물질

4

반응물 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 60352Prinomide

생성물 1

HCID 3033812Prinomide Tromethamine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 13.85 g of 1-methyl-beta-oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile in 350 ml of ethanol is added 6.1 g of tromethamine. The suspension is heated until solution is obtained and the volume is reduced to about 75 ml. The solution is cooled to crystallize the product, the salt is collected, washed with ethanol/ether and dried to yield 1-methyl-beta oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile tromethamine (1:1) salt of example 1.

후처리

  1. temperatureThe suspension is heated until solution
  2. customis obtained
  3. temperatureThe solution is cooled
  4. customto crystallize the product
  5. customthe salt is collected
  6. washwashed with ethanol/ether
  7. customdried

출처 및 근거

ORD 기록
ord-2f36f66d134640aa9594dbfdce49ba90
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04977181

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