2-Butene, 1-bromo- → Ethyl hydantoate

HRID 1111005노트

반응식

HRID 1111005 반응식
ON=CC1C=CC([NH:10][C:11]([NH:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:12])=CC=1.C[O-].[Na+].C(Br)C=CC>O>[CH2:18]([O:17][C:15]([CH2:14][NH:13][C:11](=[O:12])[NH2:10])=[O:16])[CH3:19]

참가 물질

5

반응물 3

HCID 1224142-Butene, 1-bromo-HCID 10942334Sodium MethoxideHCID 867443964-(hydroxyiminomethyl)phenyl-N'-ethoxycarbonylmethylurea

생성물 1

HCID 222535Ethyl hydantoate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of N-[4-(hydroxyiminomethyl)phenyl]-N'-ethoxycarbonylmethylurea in 25% methanolic sodium methoxide (1.0 equivalent) is treated at room temperature with 1.1 equivalent of crotyl bromide. The reaction mixture is stirred until the temperature falls to about 20° C. The reaction mixture is then poured into cold water and extracted with diethyl ether The ether solution is dried over MgSO4 and filtered, and the solvent is removed by rotary evaporator to yield the corresponding N-[4-crotyloxyiminomethyl)phenyl]-N'-ethoxycarbonylmethylurea.

후처리

  1. customfalls to about 20° C
  2. extractionextracted with diethyl ether The ether solution
  3. dry with materialis dried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed by rotary evaporator

출처 및 근거

ORD 기록
ord-2f143d14ef1843ab9fe27bc5bb02b4dc
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04977272

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