2-Butene, 1-bromo- → N'-n-propoxycarbonylmethylurea
반응식
ON=CC1C=CC([NH:10][C:11]([NH:13][CH2:14][C:15]([O:17][CH2:18][CH2:19][CH3:20])=[O:16])=[O:12])=CC=1.C[O-].[Na+].C(Br)C=CC>O>[CH2:18]([O:17][C:15]([CH2:14][NH:13][C:11](=[O:12])[NH2:10])=[O:16])[CH2:19][CH3:20]참가 물질
5
실험 절차
A solution of N-[4-(hydroxyiminomethyl)phenyl]-N'-n-propoxycarbonylmethylurea in 25% methanolic sodium methoxide (1.0 equivalent) is treated at room temperature with 1.1 equivalent of crotyl bromide. The reaction mixture is stirred until the temperature falls to about 20° C. The reaction mixture is then poured into cold water and extracted with diethyl ether. The ether solution is dried over MgSO4 and filtered, and the solvent is removed by rotary evaporator to yield the corresponding N-[4-crotyloxyiminomethyl)phenyl]-N'-n-propoxycarbonylmethylurea.
후처리
- customfalls to about 20° C
- extractionextracted with diethyl ether
- dry with materialThe ether solution is dried over MgSO4
- filtrationfiltered
- customthe solvent is removed by rotary evaporator
출처 및 근거
- ORD 기록
- ord-f525c65173264ad0a2ed900b37418fc2
- 출처 데이터셋
- uspto-grants-1990_12
- 특허 번호
- US04977272
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