2-Butene, 1-bromo- → N-[4-(1-crotyloxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea

HRID 1111020노트

반응식

HRID 1111020 반응식
[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH:14][CH2:15][C:16]([O:18][CH2:19][CH2:20][CH3:21])=[O:17])=[O:13])=[CH:7][CH:6]=1)[CH3:4].C[O-].[Na+].[CH2:25](Br)[CH:26]=[CH:27][CH3:28]>O>[CH2:25]([O:1][N:2]=[C:3]([C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]([NH:14][CH2:15][C:16]([O:18][CH2:19][CH2:20][CH3:21])=[O:17])=[O:13])=[CH:9][CH:10]=1)[CH3:4])[CH:26]=[CH:27][CH3:28]

참가 물질

5

반응물 3

HCID 1224142-Butene, 1-bromo-HCID 10942334Sodium MethoxideHCID 86742131N-[4-(1-hydroxyiminoethyl)phenyl]-N'-(n-propoxycarbonylmethyl)urea

생성물 1

HCID 54368908N-[4-(1-crotyloxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of the N-[4-(1-hydroxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea in 25% methanolic sodium methoxide (1.0 equivalent) is treated at room temperature with 1.1 equivalent of crotyl bromide. The reaction mixture is stirred until the temperature falls to about 20° C. The reaction mixture is then poured into cold water and extracted with diethyl ether. The ether solution is dried over MgSO4 and filtered, and the solvent is removed by rotary evaporator to yield the product N-[4-(1-crotyloxyiminoethyl)phenyl]-N'-n-propoxycarbonylmethylurea.

후처리

  1. customfalls to about 20° C
  2. extractionextracted with diethyl ether
  3. dry with materialThe ether solution is dried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed by rotary evaporator

출처 및 근거

ORD 기록
ord-87b9dbe3c42d4db1807b5fda61acc161
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04977272

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