Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-p-Tolylbenzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Aminophenol | HCID 5801 | — |
| 반응물 | 4-Methylbenzaldehyde | HCID 7725 | — |
| 반응물 | HCID 178418268 | HCID 178418268 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-p-Tolylbenzoxazole | HCID 70039 | — |
반응 단계
A solution of 120.2 g (1 mole) of 4-tolualdehyde and 109.1 g (1 mole) of 2-aminophenol in toluene is heated at reflux with azeotropic removal of water. After 20 hours at reflux, the reaction is cooled to room temperature, then 443.4 g (1 mole) of lead tetraacetate is added, and the mixture is stirred at room temperature for 20 hours. The solids are removed by filtration, and the filtrate is swirled with basic alumina. Removal of the solvent in vacuo affords the solid product which is then purified by recrystallization from ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04978476 |
| 출처 데이터셋 | uspto-grants-1990_12 |
| ORD ID | ord-7d9256f518ab4910a69dd2dc707f9056 |
| 출처 메모 | uspto-grants-1990_12 |