Lithium iodide → HCID 15079749, 화합물

HRID 1111221노트

반응식

HRID 1111221 반응식
C([C:7]1[N:12]2[C:13]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:14]=3[C:15]([C:18]3[C:23]([F:24])=[CH:22][CH:21]=[CH:20][C:19]=3[F:25])=[N:16][CH2:17][C:11]2=[N:10][C:9](=[O:31])[CH:8]=1)(OCCC)=O.[I-].[Li+]>N1C=CC=CC=1>[Cl:30][C:27]1[CH:28]=[CH:29][C:13]2[N:12]3[CH:7]=[CH:8][C:9](=[O:31])[N:10]=[C:11]3[CH2:17][N:16]=[C:15]([C:18]3[C:23]([F:24])=[CH:22][CH:21]=[CH:20][C:19]=3[F:25])[C:14]=2[CH:26]=1

참가 물질

4

반응물 2

HCID 66321Lithium iodideHCID 15079784HCID 15079784, 화합물

생성물 1

HCID 15079749HCID 15079749, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

In the manner given in Example 32, 1-carbopropoxy-9-chloro-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepine-3(5H)-one was heated in pyridine with lithium iodide to give 9-chloro-7-(2,6-difluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

출처 및 근거

ORD 기록
ord-4a300b51d3ae48e4bdae8550f3b87b79
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04978753

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