Boron tribromide → HCID 22152290, 화합물

HRID 1111331노트

반응식

HRID 1111331 반응식
[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[CH:6][C:7]([O:13]C)=[C:8]([CH:11]=[O:12])[CH:9]=2)[CH2:4][CH2:3]1.B(Br)(Br)Br>C(Cl)Cl>[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[CH:6][C:7]([OH:13])=[C:8]([CH:11]=[O:12])[CH:9]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 22152297HCID 22152297, 화합물

생성물 1

HCID 22152290HCID 22152290, 화합물수율 85.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4.25 g (20.8 mmol) of 1,1-dimethyl-5-methoxyindan-6-carboxaldehyde in 25 ml of methylene chloride and cooled in an ice water bath was added 22 ml (22.0 mmol, 1M in methylene chloride) of boron tribromide. After stirring for 1 h, the reaction mixture was poured into 100 ml of ice water The organic phase was dried and evaporated. The residue was chromatographed on silica gel (50 g) using hexane as eluent There was obtained 3.37 g (17.7 mmol, 85%) of 1,1-dimethyl-5-hydroxyindan-6-carboxaldehyde as a white solid; mp 40°-40.5° C.

후처리

  1. customwas dried
  2. customevaporated
  3. customThe residue was chromatographed on silica gel (50 g)

출처 및 근거

ORD 기록
ord-aaf92925cf1549f3a19c1dd0a9aa3679
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04980352

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