Triethylamine → Ethyl 11-(2-benzoyl-4-chlorobenzenesulphonamido)undecanoate

HRID 1111353노트

반응식

HRID 1111353 반응식
C(N(CC)CC)C.Cl.[NH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].[C:25]([C:33]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:34]=1[S:40](Cl)(=[O:42])=[O:41])(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(Cl)Cl>[C:25]([C:33]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:34]=1[S:40]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])(=[O:42])=[O:41])(=[O:32])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 27566002-benzoyl-4-chloro-benzenesulfonyl ChlorideHCID 13192101Ethyl 11-aminoundecanoate hydrochloride

생성물 1

HCID 22152233Ethyl 11-(2-benzoyl-4-chlorobenzenesulphonamido)undecanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

7 ml of anhydrous triethylamine are added to 5.3 g of ethyl 11-aminoundecanoate hydrochloride in 30 ml of anhydrous methylene chloride and, after stirring for one hour at ambient temperature, 6.3 g of 2-benzoyl-4-chlorobenzenesulphonyl chloride are added dropwise. After stirring for 12 hours, the reaction medium is evaporated to dryness under vacuum, taken up with water and extracted with ethyl acetate. The organic phase which is washed with water until the washings are free of Cl- ions is dried over sodium sulphate and evaporated to dryness under vacuum.

후처리

  1. stirringAfter stirring for 12 hours
  2. customthe reaction medium is evaporated to dryness under vacuum
  3. extractionextracted with ethyl acetate
  4. washThe organic phase which is washed with water until the washings
  5. dry with materialis dried over sodium sulphate
  6. customevaporated to dryness under vacuum

출처 및 근거

ORD 기록
ord-0e1e648f1e614fd5b802cf141116c059
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04980349

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