Thionyl Chloride → 2,4,5-Trifluoro-3-methoxybenzoyl chloride

HRID 1111452

반응식

HRID 1111452 반응식
[CH3:1][O:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7].S(Cl)([Cl:17])=O>>[CH3:1][O:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:17])=[O:7]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 27339702,4,5-Trifluoro-3-methoxybenzoic acid

생성물 1

HCID 27752812,4,5-Trifluoro-3-methoxybenzoyl chloride

실험 절차

To 3-methoxy-2,4,5-trifluorobenzoic acid (9.4 g) was added thionyl chloride (50 ml), the mixture was refluxed for 3 hours and then concentrated. The residue was purified by distillation under reduced pressure to give 3-methoxy-2,4,5-trifluorobenzoyl chloride (8.86 g) as yellow oil, bp 108°-112° C./20 mmHg.

후처리

  1. temperaturethe mixture was refluxed for 3 hours
  2. concentrationconcentrated
  3. distillationThe residue was purified by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-82f2bf7a88194f50bf56773d0429aff1
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04980470

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