Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-nitrobenzoate → 3-(1-Pyrrolidinyl)-4-phenoxy-5-amino-benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-nitrobenzoate | HCID 69072 | — |
| 반응물 | 3-(1-Pyrrolidinyl)-4-phenoxy-5-nitrobenzoic acid methyl ester | HCID 12498340 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3-(1-Pyrrolidinyl)-4-phenoxy-5-amino-benzoic acid methyl ester | HCID 12498341 | — |
반응 단계
A solution of 30 g of the nitrobenzoic acid methyl ester obtained according to (b) in 500 ml of dioxane is hydrogenated catalytically in the presence of Raney nickel. After completion of the absorption of hydrogen, the whole is filtered and the filtrate is concentrated. The residue yields, on recrystallization from methanol, the desired compound in the form of colourless crystals melting at 153°-156° C. in a very good yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04118397 |
| 출처 데이터셋 | uspto-grants-1978_10 |
| ORD ID | ord-8af6e775d9cb46f4831b64f9663c70d1 |
| 출처 메모 | uspto-grants-1978_10 |