Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3.4,5.6-Tetrahydrophthalimidomethyl dispiro(2.0.4.1)nonane-9-Carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | N-(Hydroxymethyl)-3,4,5,6-tetrahydrophthalimide | HCID 78597 | — |
| 반응물 | Dispiro(2.0.4.1)nonan-9-carboxylic acid | HCID 22767648 | — |
| 용매 | Benzene | HCID 241 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3.4,5.6-Tetrahydrophthalimidomethyl dispiro(2.0.4.1)nonane-9-Carboxylate | HCID 22767655 | — |
반응 단계
Dispiro(2.0.4.1)nonan-9-carboxylic acid (0.66g) was converted to the corresponding acid chloride by refluxing with thionyl chloride (1ml) in benzene (20 ml) for 1 hour. The acid chloride, N-hydroxymethyl-3,4,5,6-tetrahydrophthalimide (0.7g) and triethylamine (0.5g) were then stirred together in ether (50 ml) for 6 hours. After removal of solvent under reduced pressure the residue was purified by chromatography on silica gel using dichloromethane as eluent. The required product was obtained as an oil R.I. nD18 1.5318.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04118510 |
| 출처 데이터셋 | uspto-grants-1978_10 |
| ORD ID | ord-aaf3ae2a005040e89a8cd44fc2b3e927 |
| 출처 메모 | uspto-grants-1978_10 |