Cyanogen Bromide → 6-(Methanesulfonyl)-1H-benzimidazol-2-amine
반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([NH2:12])[CH:6]=1)(=[O:4])=[O:3].[N:13]#[C:14]Br>O>[NH2:13][C:14]1[NH:12][C:7]2[CH:6]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:10]=[CH:9][C:8]=2[N:11]=1참가 물질
4
실험 절차
One mole, 186.1 g., of 4-methylsulfonyl-o-phenylenediamine was suspended in 1.2 l. of water with stirring. One mole, 106 g., of cyanogenbromide was added portionwise to the reaction mixture. The reaction mixture was stirred for 4 hours and then filtered. Sodium hydroxide, 39 g. (1 m.) in 500 ml. of water, was added to the filtrate. The aqueous mixture was cooled in an ice bath and the product crystallized. The product was collected and dried before crystallization from ethanol-ether; yield 200 g., m.p. 233°-238° C.
후처리
- filtrationfiltered
- additionof water, was added to the filtrate
- temperatureThe aqueous mixture was cooled in an ice bath
- customthe product crystallized
- customThe product was collected
- dry with materialdried before crystallization from ethanol-ether
출처 및 근거
- ORD 기록
- ord-01280097e53f4ab884f9ec05f9d9ee2b
- 출처 데이터셋
- uspto-grants-1978_10
- 특허 번호
- US04118573
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