3-(Trifluoromethyl)phenol → 4-Chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid

반응식

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4](I)[CH:3]=1.[F:12][C:13]([F:22])([F:21])[C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([C:13]([F:12])([F:21])[F:22])[CH:15]=2)[CH:3]=1

참가 물질

반응물 2

HCID 73763-(Trifluoromethyl)phenol

HCID 1394524-Chloro-2-iodobenzoic acid

생성물 1

HCID 227678684-Chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid

실험 절차

In a manner analogous to that described in Example 1, 4-chloro-2-iodobenzoic acid is reacted with 3-trifluoromethyl-phenol, and there is obtained 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid having a melting point of 146° C.

출처 및 근거

ORD 기록: ord-dc08441b262a446db41b6dd2760444d9
출처 데이터셋: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04118572

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