Potassium Hydroxide → 3-Hydroxy-3-methyl-n-nonanoic acid

HRID 1112001

반응식

HRID 1112001 반응식
C([O:3][C:4](=[O:15])[CH2:5][C:6]([OH:14])([CH3:13])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])C.[OH-].[K+]>C(O)C>[OH:14][C:6]([CH3:13])([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:5][C:4]([OH:15])=[O:3]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 225736Ethyl 3-hydroxy-3-methylnonanoate

생성물 1

HCID 131768443-Hydroxy-3-methyl-n-nonanoic acid수율 83.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl-3-hydroxy-3-methyl-n-nonanoate (25 g) was refluxed for 3 hours with a 10% solution of potassium hydroxide in dry ethanol (210 ml). The ethanol was evaporated in vacuo and the residue was treated with water (100 ml). The aqueous solution was washed with ether then was acidified (ice-bath cooling) with dilute hydrochloric acid. The oil that separated was extracted into ether. The ether solution was washed with brine then was dried over magnesium sulphate and evaporated to give a light yellow oil. This was vacuum distilled to yield 3-hydroxy-3-methyl-n-nonanoic acid as a clear syrup (18.1g).

후처리

  1. customThe ethanol was evaporated in vacuo
  2. additionthe residue was treated with water (100 ml)
  3. washThe aqueous solution was washed with ether
  4. temperature(ice-bath cooling) with dilute hydrochloric acid
  5. customThe oil that separated
  6. extractionwas extracted into ether
  7. washThe ether solution was washed with brine
  8. dry with materialthen was dried over magnesium sulphate
  9. customevaporated
  10. customto give a light yellow oil
  11. distillationThis was vacuum distilled

출처 및 근거

ORD 기록
ord-b2b229b1603b4a2c8ccbe8eac74c430d
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04119726

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