1-Cyano-2,3-dimethylisothiourea → S-[2-((1,2,5-Thiadiazol-3-yl)methylthio)ethyl]-N-cyano-N'-methylisothiourea

반응식

BrCC1C=NSN=1.[S:8]1[N:12]=[CH:11][C:10]([CH2:13][S:14][CH2:15][CH2:16][SH:17])=[N:9]1.[C:18]([NH:20][C:21](=[N:24][CH3:25])SC)#[N:19]>>[S:8]1[N:12]=[CH:11][C:10]([CH2:13][S:14][CH2:15][CH2:16][S:17][C:21](=[N:24][CH3:25])[NH:20][C:18]#[N:19])=[N:9]1

참가 물질

반응물 3

HCID 1111031-Cyano-2,3-dimethylisothiourea

HCID 133468803-(Bromomethyl)-1,2,5-thiadiazole

HCID 203874332-((1,2,5-Thiadiazol-3-yl)methylthio)ethane thiol

생성물 1

HCID 20387419S-[2-((1,2,5-Thiadiazol-3-yl)methylthio)ethyl]-N-cyano-N'-methylisothiourea

실험 절차

Conversion of 3-bromomethyl-1,2,5-thiadiazole into 2-((1,2,5-thiadiazol-3-yl)methylthio)ethane thiol by the procedure of Example 1 and treatment of this product with N-cyano-N',S-dimethylisothiourea according to the procedure of Example 2 leads to the production of the title compound.

출처 및 근거

ORD 기록: ord-51b56695d13a4a01afdfcd6304d8e501
출처 데이터셋: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04120972

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