4-Acetamidobutyric acid → Apovincamine 4-acetamidobutyrate

HRID 1112363노트

반응식

HRID 1112363 반응식
[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[C:26]([NH:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])(=[O:28])[CH3:27]>O>[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[C:26]([NH:29][CH2:30][CH2:31][CH2:32][C:33]([O-:35])=[O:34])(=[O:28])[CH3:27]

참가 물질

4

반응물 2

HCID 181894-Acetamidobutyric acidHCID 71204Apovincamine2회

생성물 1

HCID 86736087Apovincamine 4-acetamidobutyrate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

According to the method of the preceding example, there are obtained, starting from 3.36 g of apovincamine and 1.45 g of 4-acetamidobutyric acid, 4.4 g of a product, having melting point of 128° C. and insoluble in water and alcohol. The apovincamine content of the salt is 56%.

후처리

  1. customare obtained

출처 및 근거

ORD 기록
ord-11b37757e90444128a113ffdf74c59a8
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122179

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