Benzyltriphenylphosphonium bromide → 6-Methoxy-2-[2-phenylethenyl]-1H-indole

HRID 11124

반응식

[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[C:8]([CH:12]=O)[NH:9]2)=[CH:5][CH:4]=1.[Br-].[CH2:15]([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[C:8]([CH:12]=[CH:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[NH:9]2)=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 2734970Benzyltriphenylphosphonium bromide

HCID 219806886-Methoxy-1H-indole-2-carbaldehyde

생성물 1

HCID 731231406-Methoxy-2-[2-phenylethenyl]-1H-indole수율 94%

실험 절차

Reaction of 6-methoxyindole-2-carboxaldehyde (145) with benzyltriphenylphosphonium bromide using the procedure described in example 37 gave (146) (94%) as a white solid (mixture of E/Z isomers) which was used without further purification.

출처 및 근거

ORD 기록: ord-44e17ed999e24f12a40be8ec409048b0
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07094798B1

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