Triethylamine → 2-Isopropoxy-[N-methyl-N-(4-tert-butylphenylthiosulfenyl)carbamoyloxy]benzene

HRID 1112408노트

반응식

HRID 1112408 반응식
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:3])[CH3:2].[CH3:12][N:13]([S:17][S:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:21][CH:20]=1)[C:14](F)=[O:15].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][C:14](=[O:15])[N:13]([CH3:12])[S:17][S:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([CH3:26])([CH3:28])[CH3:27])=[CH:21][CH:20]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 209492-IsopropoxyphenolHCID 23333006N-Methyl-N(4-t-Butylphenylthiosulfenyl) Carbamoyl Fluoride

생성물 1

HCID 227640382-Isopropoxy-[N-methyl-N-(4-tert-butylphenylthiosulfenyl)carbamoyloxy]benzene수율 23.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 4.0 g (0.026 m) of 2-isopropoxyphenol and 7.11 g (0.026 m) of N-methyl-N-(p-tert-butylphenylthiosulfenyl)carbamoyl fluoride in 75 ml of toluene was added 2.63 g (0.026 m) of triethylamine. After stirring for 48 hours the reaction mixture was washed with water and dried over anhydrous MgSO4. The product was purified by dry column chromatography to give 2.5g of a white solid. m.p. 84°-85° C.

후처리

  1. washwas washed with water
  2. dry with materialdried over anhydrous MgSO4
  3. customThe product was purified
  4. customby dry column chromatography

출처 및 근거

ORD 기록
ord-645733e2950348eb998225ba5213f8e8
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122204

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