1-Bromohexadecane → HCID 20396833, 화합물

HRID 1112476노트

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HRID 1112476 반응식
[CH2:1]([C:3]1[N:7]2[CH2:8][CH2:9][CH2:10][N:11]=[C:6]2[S:5][C:4]=1[CH3:12])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].[CH2:19]([Br:35])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>C(#N)C>[Br-:35].[CH2:34]([N:11]1[CH2:10][CH2:9][CH2:8][N+:7]2[C:3]([CH2:1][CH3:2])=[C:4]([CH3:12])[S:5][C:6]1=2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH3:19]

참가 물질

5

반응물 3

HCID 82131-BromohexadecaneHCID 10340Sodium CarbonateHCID 203968403-Ethyl-2-methyl-6,7-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine

생성물 1

HCID 20396833HCID 20396833, 화합물수율 18.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
0 °C

실험 절차

3-Ethyl-2-methyl-6,7-dihydro-[5H]-thiazolo[3,2-a]pyrimidine (1.8 g., 0.01 mole) (prepared by basification of the hydrobromide salt with sodium carbonate) and cetyl bromide (3.3 g., 0.011 mole) were refluxed in acetonitrile solution for 16 hours. The solvent was evaporated and the residual oil solidified by stirring under dry ether at 0° C. Recrystallization from a mixture of acetonitrile and ether gave 8-cetyl-3-ethyl-2-methyl-6,7-dihydro[5H]thiazolo[3,2-a]pyrimidinium bromide, (0.92 g., 20%), m.p. 63°-66° (Found: C, 61.4; H, 9.6; N, 5.6. C25H47N2SBr requires C, 61.6; H, 9.7; N, 5.7%).

후처리

  1. customThe solvent was evaporated
  2. customRecrystallization
  3. additionfrom a mixture of acetonitrile and ether

출처 및 근거

ORD 기록
ord-8b6a638bc16b480b8705a9eb4bd1b3bc
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122272

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