Nitric Acid → 2-Hydroxy-5-nitrobenzene-1,3-dicarboxylic acid

HRID 1112607노트

반응식

HRID 1112607 반응식
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[OH:10][C:11]1[C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>C(O)(=O)C.O>[N+:6]([C:17]1[CH:16]=[C:12]([C:13]([OH:15])=[O:14])[C:11]([OH:10])=[C:19]([CH:18]=1)[C:20]([OH:22])=[O:21])([O-:9])=[O:7]

참가 물질

6

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 118121,3-Benzenedicarboxylic acid, 2-hydroxy- (9CI)

생성물 1

HCID 128964322-Hydroxy-5-nitrobenzene-1,3-dicarboxylic acid

시약·촉매·용매 2

HCID 176Acetic Acid용매3회HCID 962Water용매

실험 절차

A mixture of 40 ml of sulfuric acid and 33 ml of nitric acid is stirred for 10 minutes and then 10 ml of acetic acid is added. To this is added a suspension of 10 g of 2-hydroxyisophthalic acid (Org. Syn., Vol. 5, p. 617) in 20 ml of acetic acid slowly with cooling in a water bath. A 10 ml portion of acetic acid is added. The reaction mixture is dissolved in water and extracted with ether. The ether is washed with saturated saline, dried over sodium sulfate and evaporated giving 5-nitro-2-hydroxyisophthalic acid as an orange oil.

후처리

  1. additionTo this is added
  2. temperaturewith cooling in a water bath
  3. extractionextracted with ether
  4. washThe ether is washed with saturated saline
  5. dry with materialdried over sodium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-9dd9740cc0884828bd29623092c19782
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04123455

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