Dichloromethane → 2,6-Dimethyl-4-(5-(1-phenyl-cyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenol

반응식

[B:1]([Br:2])([Br:3])[Br:4].[CH2:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[O:12][c:13]1[c:14]([CH3:38])[cH:15][c:16](-[c:20]2[s:21][c:22]3[n:23][c:24]([C:29]4([c:32]5[cH:33][cH:34][cH:35][cH:36][cH:37]5)[CH2:30][CH2:31]4)[cH:25][cH:26][c:27]3[n:28]2)[cH:17][c:18]1[CH3:19].[Cl:39][CH2:40][Cl:41]>>[OH:12][c:13]1[c:14]([CH3:38])[cH:15][c:16](-[c:20]2[s:21][c:22]3[n:23][c:24]([C:29]4([c:32]5[cH:33][cH:34][cH:35][cH:36][cH:37]5)[CH2:30][CH2:31]4)[cH:25][cH:26][c:27]3[n:28]2)[cH:17][c:18]1[CH3:19]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 671117832-(4-(Benzyloxy)-3,5-dimethylphenyl)-5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine

생성물 1

HCID 1363975962,6-Dimethyl-4-(5-(1-phenyl-cyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenol

출처 및 근거

ORD 기록: ord-e315f3d49b6b4e1db0e73275b9519036
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

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