Ethanolamine → 1-(2-Hydroxyethylamino)-2,16-hexadecanediol

HRID 1113

반응식

HRID 1113 반응식
[CH2:1]([CH2:3][NH2:4])[OH:2].N#N.[O:7]1[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])[CH2:8]1>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH2:8][CH:9]([OH:7])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24]

참가 물질

5

반응물 3

HCID 700Ethanolamine2회HCID 947NitrogenHCID 196946001,2-Epoxy-16-hexadecanol

생성물 1

HCID 196946261-(2-Hydroxyethylamino)-2,16-hexadecanediol수율 68%

시약·촉매·용매 1

HCID 702Ethanol용매3회

실험 절차

A 50-ml two-necked flask equipped with a stirrer, dropping funnel and N2 inlet tube was charged with 4.14 g (68 mmol) of ethanolamine and 0.8 g of ethanol. While heating and stirring the mixture at 80° C. in an N2 atmosphere, an ethanol solution of 0.87 g (3.4 mmol) of 1,2-epoxy-16-hexadecanol was added dropwise over 1.5 hours. The resultant mixture was stirred further for 2 hours at 80° C. After completion of the reaction, ethanol and excess ethanolamine were distilled off under reduced pressure, and the resultant residue was purified by flash column chromatography on silica gel, thereby obtaining 0.72 g (yield: 68%) of the title compound (IId-1).

후처리

  1. customA 50-ml two-necked flask equipped with a stirrer
  2. temperatureWhile heating
  3. distillationwere distilled off under reduced pressure
  4. customthe resultant residue was purified by flash column chromatography on silica gel

출처 및 근거

ORD 기록
ord-c54f235e113e4ef68f3a56e016403a66
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723497

연결된 노트

불러오는 중…