Sodium Iodide → 4-(2-Chlorophenyl)-8-(4-iodobutyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
반응식
FC(F)(F)S(O[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([O:36][CH3:37])=[CH:13][C:14]2[C:15]3[C:16]4[C:33](=[O:34])[NH:32][C:31](=[O:35])[C:17]=4[C:18]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[Cl:30])=[CH:19][C:20]=3[NH:21][C:22]=2[CH:23]=1)(=O)=O.[I-:40].[Na+]>C(OCC)(=O)C>[Cl:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C:18]1[C:17]2[C:31](=[O:35])[NH:32][C:33](=[O:34])[C:16]=2[C:15]2[C:14]3[CH:13]=[C:12]([O:36][CH3:37])[C:11]([CH2:10][CH2:9][CH2:8][CH2:7][I:40])=[CH:23][C:22]=3[NH:21][C:20]=2[CH:19]=1참가 물질
4
실험 절차
A mixture of the mesylate (172) 0.12 g, 0.21 mmol) prepared as described in example 311 and sodium iodide (1 g) in ethyl acetate (50 mL) was refluxed for 4 h. The cooled solution was washed with water and worked up to give the iodide (173) which crystallised from tetrahydrofuran/petroleum ether as an orange powder (0.10 g, 85%), mp 142–144° C. 1H NMR δ [(CD3)2SO] 11.86 (s, 1H), 11.05 (s, 1H), 8.43 (s, 1H), 7.58 (m, 1H), 7.55 (s, 1H), 7.52–7.43 (m, 3H), 7.42 (s, 1H), 3.94 (s, 3H). EIMS found M+=558.0212, 560.0178. C25H20ClN2O3 requires 558.0207, 560.0178.