Dimethylformamide → 5-(8-(((trans)-4-Methoxycyclohexyl)methyl)-7-oxo-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl)-4-methylpicolinonitrile

HRID 1114348

반응식

HRID 1114348 반응식
[Br:25][c:26]1[c:27]([CH3:34])[cH:28][c:29]([C:32]#[N:33])[n:30][cH:31]1.[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][CH:6]([CH2:9][N:10]2[C:11](=[O:24])[CH2:12][NH:13][c:14]3[c:15]2[n:16][c:17]([Sn:20]([CH3:21])([CH3:22])[CH3:23])[cH:18][n:19]3)[CH2:7][CH2:8]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:98][N:99]([CH3:100])[CH:101]=[O:102].[O:44]=[C:45]([CH:46]=[CH:47][c:48]1[cH:49][cH:50][cH:51][cH:52][cH:53]1)[CH:54]=[CH:55][c:56]1[cH:57][cH:58][cH:59][cH:60][cH:61]1.[O:62]=[C:63]([CH:64]=[CH:65][c:66]1[cH:67][cH:68][cH:69][cH:70][cH:71]1)[CH:72]=[CH:73][c:74]1[cH:75][cH:76][cH:77][cH:78][cH:79]1.[O:80]=[C:81]([CH:82]=[CH:83][c:84]1[cH:85][cH:86][cH:87][cH:88][cH:89]1)[CH:90]=[CH:91][c:92]1[cH:93][cH:94][cH:95][cH:96][cH:97]1.[Pd:42].[Pd:43]>>[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][CH:6]([CH2:9][N:10]2[C:11](=[O:24])[CH2:12][NH:13][c:14]3[c:15]2[n:16][c:17](-[c:26]2[c:27]([CH3:34])[cH:28][c:29]([C:32]#[N:33])[n:30][cH:31]2)[cH:18][n:19]3)[CH2:7][CH2:8]1

참가 물질

7

반응물 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 23938Palladium2회HCID 95417Dibenzylidene acetone3회HCID 533954685-Bromo-4-methylpyridine-2-carbonitrileHCID 666074241-(((trans)-4-Methoxycyclohexyl)methyl)-7-(trimethylstannyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

생성물 1

HCID 666077375-(8-(((trans)-4-Methoxycyclohexyl)methyl)-7-oxo-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl)-4-methylpicolinonitrile

출처 및 근거

ORD 기록
ord-be946c7e8de840f7a8bd1eb9520d1779
출처 데이터셋
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

연결된 노트

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