7-Bromo-4-(2-chlorophenyl)-9-hydroxy-1H-[1]benzofuro[3,2-e]isoindole-1,3(2H)-dione → 4-(2-Chlorophenyl)-9-hydroxy-7-vinyl-1H-[1]benzofuro[3,2-e]isoindole-1,3(2H)-dione

HRID 11155

반응식

HRID 11155 반응식
Br[C:2]1[C:7]2[O:8][C:9]3[CH:17]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[Cl:24])[C:15]4[C:14](=[O:25])[NH:13][C:12](=[O:26])[C:11]=4[C:10]=3[C:6]=2[CH:5]=[C:4]([OH:27])[CH:3]=1.[CH2:28](C([Sn])=C(CCCC)CCCC)[CH2:29]CC>>[Cl:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16]1[C:15]2[C:14](=[O:25])[NH:13][C:12](=[O:26])[C:11]=2[C:10]2[C:6]3[CH:5]=[C:4]([OH:27])[CH:3]=[C:2]([CH:28]=[CH2:29])[C:7]=3[O:8][C:9]=2[CH:17]=1

참가 물질

3

반응물 2

HCID 219804697-Bromo-4-(2-chlorophenyl)-9-hydroxy-1H-[1]benzofuro[3,2-e]isoindole-1,3(2H)-dioneHCID 53438229Tri(butyl)vinyltin

생성물 1

HCID 219807084-(2-Chlorophenyl)-9-hydroxy-7-vinyl-1H-[1]benzofuro[3,2-e]isoindole-1,3(2H)-dione수율 79%

실험 절차

Reaction of (862) prepared as described in example 443 with tributylvinyltin using the procedure described in example 309 gave (863) (79%). 1H NMR δ [(CD3)2SO] 9.80 (s, 1H), 8.04 (d, J=2.7 Hz, 1H), 7.91 (s, 1H), 7.56 (d, J=8 Hz, 1H), 7.45 (m, 3H), 7.2 (d, J=2.5 Hz, 1H), 6.96 (dd, J=18,1 Hz, 1H), 6.25 (d, J=18 Hz, 1H), 5.52 (d, J=11 Hz, 1H). MH−:390,388.

후처리

  1. customprepared

출처 및 근거

ORD 기록
ord-38c5ff3602ab40bb85dea69ba1ea2eba
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094798B1

연결된 노트

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