Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanoacetamide → HCID 178418929, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanoacetamide | HCID 7898 | — |
| 반응물 | Ethyl Acetoacetate | HCID 8868 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 생성물 | HCID 178418929 | HCID 178418929 | — |
반응 단계
Amine was generated by the condensation of ethylacetoacetate with cyanoacetamide followed by reaction with phosphorus oxychloride to provide 3-cyano-2,5-dihydroxy-4-methylpyridine. Hydrogenation with palladium dichloride gave the 3-cyano-4-methylpyridine which was hydrogenated with Raney nickel in ammonia and ethanol to afford the desired amine (J. Org. Chem. 1959, 25, 560.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094909B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-3a88dd9b299e453abb8cca072f727e81 |
| 출처 메모 | uspto-grants-2006_08 |