Water → 5-((Tert-butyldimethylsilyl)oxy)-1-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-2-methylenepentan-1-one

HRID 1119902노트

반응식

[Br:1][C:2]([CH2:3][CH2:4][CH2:5][O:6][Si:7]([CH3:8])([CH3:9])[C:10]([CH3:11])([CH3:12])[CH3:13])=[CH2:14].[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[F:17][c:18]1[c:19]([CH:20]=[O:21])[cH:22][c:23](-[c:27]2[cH:28][n:29][cH:30][n:31][cH:32]2)[c:24]([F:26])[cH:25]1.[I:16].[Mg:15].[OH2:38]>>[C:2]([CH2:3][CH2:4][CH2:5][O:6][Si:7]([CH3:8])([CH3:9])[C:10]([CH3:11])([CH3:12])[CH3:13])(=[CH2:14])[C:20]([c:19]1[c:18]([F:17])[cH:25][c:24]([F:26])[c:23](-[c:27]2[cH:28][n:29][cH:30][n:31][cH:32]2)[cH:22]1)=[O:21]