Benzene → 1,2-Epoxy-3-tridecanol

HRID 1120

반응식

HRID 1120 반응식
[CH2:1]=[CH:2][CH:3]([OH:14])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].ClC1C=CC=C(C(OO)=[O:23])C=1.C1C=CC=CC=1>CCCCCC>[O:23]1[CH:2]([CH:3]([OH:14])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:1]1

참가 물질

5

반응물 3

HCID 241BenzeneHCID 70297m-Chloroperbenzoic acidHCID 185797Tridec-1-en-3-ol

생성물 1

HCID 134206171,2-Epoxy-3-tridecanol수율 74%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

A 500-ml flask equipped with a stirrer was charged with 23.8 g (0.12 mol) of 1-tridecen-3-ol, 25.0 g (0.145 mol) of m-chloroperbenzoic acid and 250 ml of benzene, and the contents were stirred at room temperature for 48 hours. After completion of the reaction, 200 ml of hexane. Solids deposited were separated by filtration, and the solvent was distilled off under reduced pressure. The resultant residue was purified by column chromatography on silica gel, thereby obtaining 19.0 g (yield: 74%) of 1,2-epoxy-3-tridecanol.

후처리

  1. customA 500-ml flask equipped with a stirrer
  2. customSolids deposited were separated by filtration
  3. distillationthe solvent was distilled off under reduced pressure
  4. customThe resultant residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-336388df5b80425486bbf74ea75cd7c9
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723497

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