Benzyl Bromide → 1-Bromo-4-phenylmethoxybenzene

HRID 11201

반응식

HRID 11201 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CC(C)=O.C(OCC)(=O)C.O>[CH2:15]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

7

반응물 3

HCID 7498Benzyl BromideHCID 78084-BromophenolHCID 11430Potassium Carbonate

생성물 1

HCID 1388351-Bromo-4-phenylmethoxybenzene

시약·촉매·용매 3

HCID 180Acetone용매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5–6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

후처리

  1. temperatureThe reaction was refluxed under nitrogen
  2. temperatureAfter 5–6 hours of reflux
  3. customthe organic layer was separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated to dryness
  6. customto afford a white fluffy powder

출처 및 근거

ORD 기록
ord-9c38a67482a74a60b22a9dd04f69b8a7
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07097995B2

연결된 노트

불러오는 중…