Dichloromethane → 3-(3-Chloropyridin-2-yl)-3,8-diazabicyclo[3.2.1]octane

반응식

[Cl:1][c:2]1[c:3]([N:8]2[CH2:9][CH:10]3[CH2:11][CH2:12][CH:13]([CH2:14]2)[N:15]3[C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[n:4][cH:5][cH:6][cH:7]1.[Cl:30][CH2:31][Cl:32].[OH:23][C:24]([C:25]([F:26])([F:27])[F:28])=[O:29]>>[Cl:1][c:2]1[c:3]([N:8]2[CH2:9][CH:10]3[CH2:11][CH2:12][CH:13]([CH2:14]2)[NH:15]3)[n:4][cH:5][cH:6][cH:7]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 21904762Tert-butyl 3-(3-chloro-2-pyridinyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

생성물 1

HCID 219047683-(3-Chloropyridin-2-yl)-3,8-diazabicyclo[3.2.1]octane

출처 및 근거

ORD 기록: ord-978335f8197242c2a0b225a2855b6f4c
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

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